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Titre : Chemical Biology : Learning through Case Studies Type de document : texte imprimé Auteurs : Herbert waldmann, Auteur ; Petra Janning, Auteur Editeur : Wiley VCH Année de publication : 2009 Importance : ‎271p. Présentation : ill. Format : 24cmx17cm ISBN/ISSN/EAN : 978-3-527-32330-2 Langues : Anglais (eng) Langues originales : Anglais (eng) Index. décimale : 574 Résumé : .
-This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion.
-Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to think in order to solve problems in biology by using techniques and tools taken from chemistry.
A must-have for students in chemistry, biology and biochemistry.Note de contenu : .
Sommaire:
Table of contents
Yeast-based chemical genomic approache
Chemogenomic profiling: elucidating the mode of action of small molecules
Mircoarray-based strategies to identify unknown protein interaction
Chemical biological research/evaluation
Compound collection synthesis for chemical biolog
A chemical question with biological consequences
Target identification and validation of a wnt/beta-catenin pathway modulator
Chemical biological research/evaluation
Activity-based protein profiling of cys proteases
Chemical biological research/evaluation
The use of photoaffinity labeling for the identification of the binding site of the antibiotic linezolid
Chemical biological research/evaluation
Surgical strikes: uses of analog sensitive technologies to target kinases of interest
Chemical biological research/evaluation: aska technology -
Applications in molecular biology
Modulation of protein-protein interactions by small molecules
Chemical biological research/evaluation
Targeted protein degradation in live cells
Trapoxin b: from total synthesis to epigenetics
Chemical biological research/evaluation
Native chemial ligation -
A tool for chemical prothe synthetic challeng
Native chemical ligation
Chemical biological research/evaluation -
The ras-rbd systems
Using split inteins to prepare semi-synthetic proteins and to study the mechanisms of protein trans-splicing
Chemical biological research/evaluation
Elucidation of the ras cycle with semi-synthetic proteins
Chemical biological research/evaluation
The study of rab gtpase recycling using semi-synthetic prenylated proteins
Introduction
The biological problem
The chemical approach
Chemical biological research/evaluation
Development of a model cancer vaccine candidate based on the mucl cellular surface glycopeptide epitope
Chemical biological research/evaluation
The introduction of chemical reporter groups by bioorthogonal ligation reactions for the imaging of cell-surface glycans
Chemical biological research/evaluation
Sequence specific dna-binding small molecules for protein recruitment and modulation of transcription
Targeting dna with small molecules
The chemical approach: the polyamide rationale
Chemical biological research/evaluation -
Polyamides in biological applications
G-quadruplex ligands as tools for elucidating c-myc transcriptional regulatio
Chemical biological research/evaluation
Conclusion
RéférenceEn ligne : https://media.wiley.com/product_data/coverImage300/09/35273233/3527323309.jpg Chemical Biology : Learning through Case Studies [texte imprimé] / Herbert waldmann, Auteur ; Petra Janning, Auteur . - [S.l.] : Wiley VCH, 2009 . - ‎271p. : ill. ; 24cmx17cm.
ISBN : 978-3-527-32330-2
Langues : Anglais (eng) Langues originales : Anglais (eng)
Index. décimale : 574 Résumé : .
-This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion.
-Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to think in order to solve problems in biology by using techniques and tools taken from chemistry.
A must-have for students in chemistry, biology and biochemistry.Note de contenu : .
Sommaire:
Table of contents
Yeast-based chemical genomic approache
Chemogenomic profiling: elucidating the mode of action of small molecules
Mircoarray-based strategies to identify unknown protein interaction
Chemical biological research/evaluation
Compound collection synthesis for chemical biolog
A chemical question with biological consequences
Target identification and validation of a wnt/beta-catenin pathway modulator
Chemical biological research/evaluation
Activity-based protein profiling of cys proteases
Chemical biological research/evaluation
The use of photoaffinity labeling for the identification of the binding site of the antibiotic linezolid
Chemical biological research/evaluation
Surgical strikes: uses of analog sensitive technologies to target kinases of interest
Chemical biological research/evaluation: aska technology -
Applications in molecular biology
Modulation of protein-protein interactions by small molecules
Chemical biological research/evaluation
Targeted protein degradation in live cells
Trapoxin b: from total synthesis to epigenetics
Chemical biological research/evaluation
Native chemial ligation -
A tool for chemical prothe synthetic challeng
Native chemical ligation
Chemical biological research/evaluation -
The ras-rbd systems
Using split inteins to prepare semi-synthetic proteins and to study the mechanisms of protein trans-splicing
Chemical biological research/evaluation
Elucidation of the ras cycle with semi-synthetic proteins
Chemical biological research/evaluation
The study of rab gtpase recycling using semi-synthetic prenylated proteins
Introduction
The biological problem
The chemical approach
Chemical biological research/evaluation
Development of a model cancer vaccine candidate based on the mucl cellular surface glycopeptide epitope
Chemical biological research/evaluation
The introduction of chemical reporter groups by bioorthogonal ligation reactions for the imaging of cell-surface glycans
Chemical biological research/evaluation
Sequence specific dna-binding small molecules for protein recruitment and modulation of transcription
Targeting dna with small molecules
The chemical approach: the polyamide rationale
Chemical biological research/evaluation -
Polyamides in biological applications
G-quadruplex ligands as tools for elucidating c-myc transcriptional regulatio
Chemical biological research/evaluation
Conclusion
RéférenceEn ligne : https://media.wiley.com/product_data/coverImage300/09/35273233/3527323309.jpg Réservation
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Code-barres Cote Support Localisation Section Disponibilité 11/185847 L/574.159 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185848 L/574.159 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185849 L/574.159 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185850 L/574.159 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185851 L/574.159 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible
Titre : Quantum Biochemistry : Volume 1 : Electronic structure and biological activity Type de document : texte imprimé Auteurs : Chérif F Matta, Auteur Editeur : Wiley VCH Année de publication : 2010 Importance : 498p. Présentation : ill. Format : 24.5 cm×17cm ISBN/ISSN/EAN : 978-3-527-32322-7 Langues : Anglais (eng) Langues originales : Anglais (eng) Index. décimale : 574 Résumé : .
Divided into five major parts, the two volumes of this ready reference cover the tailoring of theoretical methods for biochemical computations, as well as the many kinds of biomolecules, reaction and transition state elucidation, conformational flexibility determination, and drug design. Throughout, the chapters gradually build up from introductory level to comprehensive reviews of the latest research, and include all important compound classes, such as DNA, RNA, enzymes, vitamins, and heterocyclic compounds.
The result is in-depth and vital knowledge for both readers already working in the field as well as those entering it. Includes contributions by Prof. Ada Yonath (Nobel Prize in Chemistry 2009) and Prof. Jerome Karle (Nobel Prize in Chemistry 1985).Note de contenu : .
Summary:
Volume one:
PART 1:Novel Theoretical , Computational, and Experimental Methods and Techniques
Quantum kernels and quantum crystallography: applications in biochemistry:
Introduction
Origins of Quantum Crystallography (QCr)
Beginnings of Quantum Kernels
Kernel Density Matrices Led to Kernel Energies
Summary and Conclusions
Getting the most out of oniom: guidelines and pitfalls:
Introduction
QM/MM
ONIOM
Guidelines for the Application of ONIOM
Use of Point charges
Conclusions
Modeling enzymatic reactions in metalloenzymes and photobiology by quantum mechanics (qm) and quantum mechanics/molecular mechanics (qm/mm) calculations:
Introduction
Computational Strategies (Methods and Models)
Metalloenzymes
Photobiology
Conclusion
From molecular electrostatic potentials to solvation models and ending with biomolecular photophysical processes:
Introduction
The Molecular Electrostatic Potential and Noncovalent Interactions among Molecules
Solvation: The "Continuum Model"
Applications of the PCM Method
The fast marching method for determining chemical reaction mechanisms in complex systems:
Motivation
Background
Fast Marching Method
Quantum Mechanics/Molecular Mechanics (QM/MM) Methods Applied to Enzyme-Catalyzed Reactions
Summary
PART2: Nucleic Acids, Amino Acids, Peptides and Their Interactions
Chemical origin of life: how do five hcn molecules combine to form adenine under prebiotic and interstallar conditions:
Introduction
Prebiotic Chemistry: Experimental Endeavor to Synthesize the Building Blocks of Biopolymers
Computational Investigation
Conclusion
Hydrogen bonding and proton transfer in ionized dna base pairs, amino acids and peptides:
Introduction
Methodological Aspects
Ionization of DNA Base Pairs
Ionization of Amino Acids
Ionization of Peptides
Conclusions
To nano-biochemistry: picture of the interactions of dna with gold:
Introductory Nanoscience Background
DNA-Gold Bonding Patterns: Some Experimental Facts
Adenine-Gold Interaction
Guanine-Gold Interaction
Thymine-Gold Interactions
Cytosine-Gold Interactions
Basic Trends of DNA Base-Gold Interaction
Interaction of Watson-Crick DNA Base Pairs with Gold Clusters
Summary and Perspectives
Quantum mechanical studies of noncovalent dna-protein interactions:
Introduction
Computational Approaches for Studying Noncovalent Interactions
Hydrogen-Bonding Interactions
Interactions between Aromatic DNA-Protein Components
Cation-pi Interactions between DNA-Protein Components
Conclusions
The virial field and transferability in dna base-pairing:
A New Theorem Relating the Density of an Atom in a Molecule to the Energy
Computations
Chemical Transferability and the One-Electron Density Matrix
Changes in Atomic Energies Encountered in DNA Base Pairing
Energy Changes in the WC Pairs GC and AT
Discussion
An electron density-based approach to the origin of stacking interactions:
Introduction
Computational Method
Charge-Transfer Complexes: Quinhydrone
pi-pi Interactions in Hetero-Molecular Complexes: Methyl Gallate-Caffeine Adduct
pi-pi Interactions between DNA Base Pair Steps
pi-pi Interactions in Homo-Molecular Complexes: Catechol
C-H/pi Complexes
Provisional Conclusions and Future Research
Polarizabilities of amino acids: additive models and ab initio calculations:
Introduction
Models of Polarizability
Polarizabilities of the Amino Acids
Concluding Remarks
Methods in biocomputational chemistry: a lesson from the amino acids:
Introduction
Conformers, Rotamers and Physicochemical Variables
QTAIM Side Chain Polarizations and the Theoretical Classification of Amino Acids
Quantum Mechanical Studies of Peptide-Host Interactions
Conclusions
From atoms in amino acids to the genetic code and protein stability, and backwards:
Context of the Work
The Electron Density rho(r) as an Indirectly Measurable Dirac Observable
Brief Review of Some Basic Concepts of the Quantum Theory of Atoms in Molecules
Computational Approach and Level of Theory
Empirical Correlations of QTAIM Atomic Properties of Amino Acid Side Chains with Experiment
Molecular Complementarity
Closing Remarks
Appendix A: X-Ray and Neutron Diffraction Geometries of the Amino Acids in the Literature
Energy richness of atp in terms of atomic energies: a first step:
Introduction
How "(De)Localized" is the Enthalpy of Bond Dissociation?
The Choice of a Theoretical Level
Computational Details
(Global) Energies of the Hydrolysis of ATP in the Absence and Presence of Mg2+
How "(De)Localized" is the Energy of Hydrolysis of ATP?
Other Changes upon Hydrolysis of ATP in the Presence and Absence of Mg2+
ConclusionsEn ligne : http://www.cmatta.ca/wp-content/uploads/cover_Vol1210wide-208x300.jpg Quantum Biochemistry : Volume 1 : Electronic structure and biological activity [texte imprimé] / Chérif F Matta, Auteur . - [S.l.] : Wiley VCH, 2010 . - 498p. : ill. ; 24.5 cm×17cm.
ISBN : 978-3-527-32322-7
Langues : Anglais (eng) Langues originales : Anglais (eng)
Index. décimale : 574 Résumé : .
Divided into five major parts, the two volumes of this ready reference cover the tailoring of theoretical methods for biochemical computations, as well as the many kinds of biomolecules, reaction and transition state elucidation, conformational flexibility determination, and drug design. Throughout, the chapters gradually build up from introductory level to comprehensive reviews of the latest research, and include all important compound classes, such as DNA, RNA, enzymes, vitamins, and heterocyclic compounds.
The result is in-depth and vital knowledge for both readers already working in the field as well as those entering it. Includes contributions by Prof. Ada Yonath (Nobel Prize in Chemistry 2009) and Prof. Jerome Karle (Nobel Prize in Chemistry 1985).Note de contenu : .
Summary:
Volume one:
PART 1:Novel Theoretical , Computational, and Experimental Methods and Techniques
Quantum kernels and quantum crystallography: applications in biochemistry:
Introduction
Origins of Quantum Crystallography (QCr)
Beginnings of Quantum Kernels
Kernel Density Matrices Led to Kernel Energies
Summary and Conclusions
Getting the most out of oniom: guidelines and pitfalls:
Introduction
QM/MM
ONIOM
Guidelines for the Application of ONIOM
Use of Point charges
Conclusions
Modeling enzymatic reactions in metalloenzymes and photobiology by quantum mechanics (qm) and quantum mechanics/molecular mechanics (qm/mm) calculations:
Introduction
Computational Strategies (Methods and Models)
Metalloenzymes
Photobiology
Conclusion
From molecular electrostatic potentials to solvation models and ending with biomolecular photophysical processes:
Introduction
The Molecular Electrostatic Potential and Noncovalent Interactions among Molecules
Solvation: The "Continuum Model"
Applications of the PCM Method
The fast marching method for determining chemical reaction mechanisms in complex systems:
Motivation
Background
Fast Marching Method
Quantum Mechanics/Molecular Mechanics (QM/MM) Methods Applied to Enzyme-Catalyzed Reactions
Summary
PART2: Nucleic Acids, Amino Acids, Peptides and Their Interactions
Chemical origin of life: how do five hcn molecules combine to form adenine under prebiotic and interstallar conditions:
Introduction
Prebiotic Chemistry: Experimental Endeavor to Synthesize the Building Blocks of Biopolymers
Computational Investigation
Conclusion
Hydrogen bonding and proton transfer in ionized dna base pairs, amino acids and peptides:
Introduction
Methodological Aspects
Ionization of DNA Base Pairs
Ionization of Amino Acids
Ionization of Peptides
Conclusions
To nano-biochemistry: picture of the interactions of dna with gold:
Introductory Nanoscience Background
DNA-Gold Bonding Patterns: Some Experimental Facts
Adenine-Gold Interaction
Guanine-Gold Interaction
Thymine-Gold Interactions
Cytosine-Gold Interactions
Basic Trends of DNA Base-Gold Interaction
Interaction of Watson-Crick DNA Base Pairs with Gold Clusters
Summary and Perspectives
Quantum mechanical studies of noncovalent dna-protein interactions:
Introduction
Computational Approaches for Studying Noncovalent Interactions
Hydrogen-Bonding Interactions
Interactions between Aromatic DNA-Protein Components
Cation-pi Interactions between DNA-Protein Components
Conclusions
The virial field and transferability in dna base-pairing:
A New Theorem Relating the Density of an Atom in a Molecule to the Energy
Computations
Chemical Transferability and the One-Electron Density Matrix
Changes in Atomic Energies Encountered in DNA Base Pairing
Energy Changes in the WC Pairs GC and AT
Discussion
An electron density-based approach to the origin of stacking interactions:
Introduction
Computational Method
Charge-Transfer Complexes: Quinhydrone
pi-pi Interactions in Hetero-Molecular Complexes: Methyl Gallate-Caffeine Adduct
pi-pi Interactions between DNA Base Pair Steps
pi-pi Interactions in Homo-Molecular Complexes: Catechol
C-H/pi Complexes
Provisional Conclusions and Future Research
Polarizabilities of amino acids: additive models and ab initio calculations:
Introduction
Models of Polarizability
Polarizabilities of the Amino Acids
Concluding Remarks
Methods in biocomputational chemistry: a lesson from the amino acids:
Introduction
Conformers, Rotamers and Physicochemical Variables
QTAIM Side Chain Polarizations and the Theoretical Classification of Amino Acids
Quantum Mechanical Studies of Peptide-Host Interactions
Conclusions
From atoms in amino acids to the genetic code and protein stability, and backwards:
Context of the Work
The Electron Density rho(r) as an Indirectly Measurable Dirac Observable
Brief Review of Some Basic Concepts of the Quantum Theory of Atoms in Molecules
Computational Approach and Level of Theory
Empirical Correlations of QTAIM Atomic Properties of Amino Acid Side Chains with Experiment
Molecular Complementarity
Closing Remarks
Appendix A: X-Ray and Neutron Diffraction Geometries of the Amino Acids in the Literature
Energy richness of atp in terms of atomic energies: a first step:
Introduction
How "(De)Localized" is the Enthalpy of Bond Dissociation?
The Choice of a Theoretical Level
Computational Details
(Global) Energies of the Hydrolysis of ATP in the Absence and Presence of Mg2+
How "(De)Localized" is the Energy of Hydrolysis of ATP?
Other Changes upon Hydrolysis of ATP in the Presence and Absence of Mg2+
ConclusionsEn ligne : http://www.cmatta.ca/wp-content/uploads/cover_Vol1210wide-208x300.jpg Réservation
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Code-barres Cote Support Localisation Section Disponibilité 11/185936 L/574.162 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185935 L/574.162 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible
Titre : RNA purification and analysis : sample preparation, extraction, chromatography Type de document : texte imprimé Auteurs : Douglas T.Gjerde, Auteur ; Lee Hoang, Auteur ; David Hornby, Auteur Editeur : Wiley VCH Année de publication : 2009 Importance : 195p. Présentation : ill. Format : 24,5 cm x 17cm ISBN/ISSN/EAN : 978-3-527-32116-2 Langues : Anglais (eng) Langues originales : Anglais (eng) Index. décimale : 574 Résumé : .
The complete know how on optimizing lab protocols for handling every RNA species from the very small to the very large.
In contrast to DNA, which is restricted to the single function of carrier of genetic information in the cell nucleus, RNA a closely related but biochemically very different molecule, is employed in a variety of functions. Consequently, there are dozens of functionally different RNA classes in the cell. Their analysis and selective enrichment requires special knowledge and special tools, many of which have been substantially improved in recent years.
This is the first book on the market to cover the many new and important RNA species discovered over the past five years, and it explains current methods for their enrichment, separation and purification.
Building up from general principles of RNA biochemistry and biophysics, it addresses the practical aspects relevant to the laboratory researcher throughout, while discussing the performance and potential problems of the methods discussed.Note de contenu : .
Content
Rna extraction, separation and analysis:
The need to be able to extract, manipulate and analyze RNA
Using chemical tools to solve the problem of analysis of biological problems
The principle of chromatography and solid phase extraction
RNA Chromatography
Enzymatic treatment of RNA and analysis
Content and organization of this book
Biological and chemical rna:
Why Classify RNA with biology and chemistry?
Prokaryote cellular RNA
Prokaryote sample type
Eukaryote cellular RNA
Eukaryote sample type
Other Samples (Virus, Soil, Rock)
Synthetic RNA
Rna separation -
Substrates, functional groups, mechanisms and control:
Solid phase interaction
The solid phase substrate and attachment of functional groups
Reverse phase ion pairing separation mechanism
Ion exchange separation mechanism
Chaotropic denaturing interaction mechanism
Hybridization /
SELEX
Gel Filtration
Rna extraction and analysis:
Transcription
Translation
Gene regulation
Use of siRNA to investigate gene function
Rna chromatography:
Development of RNA Chromatography
RNA Chromatography instrumentation
RNA Chromatography conditions
Temperature modes of RNA Chromatography
Comparison of gel electrophoresis and liquid chromatography
Analysis of human telomerase RNA under non denaturing conditions
Rna chromatography, separation and analysis:
Features of RNA Chromatography
Separation of double-stranded and single-stranded RNA
Separation of cellular RNA species
Separation of messenger RNA from total and ribosomal RNA
Analysis of transfer RNA
Chromatography and analysis of synthetic oligo ribonucleotides
Application of RNA and DNA Chromatography in cDNA library synthesis
Chromatography analyses of RT-PCR and competitive RT-PCR products
Alternative splicing
Differential messenger RNA display via RNA Chromatography
Rna structure-function probing:
Definition of the Structure-function paradigm
Structure determination of RNA
Footprinting, model building and functional investigations
APPENDIX
Chromatographic Separation Equotations and Priciples for RNA Separation
HPLC Instrumentation and Operation
RNA Chromatographic System Cleaning and Passivation TreatmentEn ligne : https://media.wiley.com/product_data/coverImage300/60/35273211/3527321160.jpg RNA purification and analysis : sample preparation, extraction, chromatography [texte imprimé] / Douglas T.Gjerde, Auteur ; Lee Hoang, Auteur ; David Hornby, Auteur . - [S.l.] : Wiley VCH, 2009 . - 195p. : ill. ; 24,5 cm x 17cm.
ISBN : 978-3-527-32116-2
Langues : Anglais (eng) Langues originales : Anglais (eng)
Index. décimale : 574 Résumé : .
The complete know how on optimizing lab protocols for handling every RNA species from the very small to the very large.
In contrast to DNA, which is restricted to the single function of carrier of genetic information in the cell nucleus, RNA a closely related but biochemically very different molecule, is employed in a variety of functions. Consequently, there are dozens of functionally different RNA classes in the cell. Their analysis and selective enrichment requires special knowledge and special tools, many of which have been substantially improved in recent years.
This is the first book on the market to cover the many new and important RNA species discovered over the past five years, and it explains current methods for their enrichment, separation and purification.
Building up from general principles of RNA biochemistry and biophysics, it addresses the practical aspects relevant to the laboratory researcher throughout, while discussing the performance and potential problems of the methods discussed.Note de contenu : .
Content
Rna extraction, separation and analysis:
The need to be able to extract, manipulate and analyze RNA
Using chemical tools to solve the problem of analysis of biological problems
The principle of chromatography and solid phase extraction
RNA Chromatography
Enzymatic treatment of RNA and analysis
Content and organization of this book
Biological and chemical rna:
Why Classify RNA with biology and chemistry?
Prokaryote cellular RNA
Prokaryote sample type
Eukaryote cellular RNA
Eukaryote sample type
Other Samples (Virus, Soil, Rock)
Synthetic RNA
Rna separation -
Substrates, functional groups, mechanisms and control:
Solid phase interaction
The solid phase substrate and attachment of functional groups
Reverse phase ion pairing separation mechanism
Ion exchange separation mechanism
Chaotropic denaturing interaction mechanism
Hybridization /
SELEX
Gel Filtration
Rna extraction and analysis:
Transcription
Translation
Gene regulation
Use of siRNA to investigate gene function
Rna chromatography:
Development of RNA Chromatography
RNA Chromatography instrumentation
RNA Chromatography conditions
Temperature modes of RNA Chromatography
Comparison of gel electrophoresis and liquid chromatography
Analysis of human telomerase RNA under non denaturing conditions
Rna chromatography, separation and analysis:
Features of RNA Chromatography
Separation of double-stranded and single-stranded RNA
Separation of cellular RNA species
Separation of messenger RNA from total and ribosomal RNA
Analysis of transfer RNA
Chromatography and analysis of synthetic oligo ribonucleotides
Application of RNA and DNA Chromatography in cDNA library synthesis
Chromatography analyses of RT-PCR and competitive RT-PCR products
Alternative splicing
Differential messenger RNA display via RNA Chromatography
Rna structure-function probing:
Definition of the Structure-function paradigm
Structure determination of RNA
Footprinting, model building and functional investigations
APPENDIX
Chromatographic Separation Equotations and Priciples for RNA Separation
HPLC Instrumentation and Operation
RNA Chromatographic System Cleaning and Passivation TreatmentEn ligne : https://media.wiley.com/product_data/coverImage300/60/35273211/3527321160.jpg Réservation
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Code-barres Cote Support Localisation Section Disponibilité 11/186040 L/574.171 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/186039 L/574.171 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible The Chemical Biology of DNA Damage / Nicholas E.Geacintov
Titre : The Chemical Biology of DNA Damage Type de document : texte imprimé Auteurs : Nicholas E.Geacintov, Auteur Editeur : Wiley VCH Année de publication : 2010 Importance : 449p. Présentation : ill Format : 25cm X18.3cm ISBN/ISSN/EAN : 978-3-527-32295-4 Langues : Anglais (eng) Langues originales : Anglais (eng) Index. décimale : 574 Résumé : Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.
A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.The Chemical Biology of DNA Damage [texte imprimé] / Nicholas E.Geacintov, Auteur . - [S.l.] : Wiley VCH, 2010 . - 449p. : ill ; 25cm X18.3cm.
ISBN : 978-3-527-32295-4
Langues : Anglais (eng) Langues originales : Anglais (eng)
Index. décimale : 574 Résumé : Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.
A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.Réservation
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Code-barres Cote Support Localisation Section Disponibilité 11/186043 L/574.172 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/186042 L/574.172 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible Toxicogenomics: A Powerful Tool for Toxicity Assessment / Saura C Sahu
Titre : Toxicogenomics: A Powerful Tool for Toxicity Assessment Type de document : texte imprimé Auteurs : Saura C Sahu, Auteur Editeur : Wiley VCH Année de publication : 2011 Importance : 409p Présentation : ill Format : 26x 18 cm ISBN/ISSN/EAN : 978-0-470-51823-6 Langues : Anglais (eng) Langues originales : Anglais (eng) Index. décimale : 616 Maladies Résumé :
Toxicogenomics is the integration of genomics to toxicology. Thistechnology is a powerful tool for collecting information from alarge number of biological samples simultaneously and thus it isvery useful for large–scale screening of potential toxicants.
Toxicogenomics: A Powerful Tool For Toxicity Assessmentprovides up–to–date state–of–the–art information presented by therecognized experts, and is therefore an authoritative source ofcurrent knowledge in this field of research. The potential linkbetween toxicology, genetics and human diseases makes this bookvery useful to investigators in many and varied disciplines ofscience and toxicology. Topics covered include:
*mechanistic toxicogenomics
*analysis and interpretation of toxicogenomic data
*principles of data mining in toxicogenomics
*design issues in toxicogenomics studies
*sources of variability in toxicogenomic assays
*Escherichia coli stress response as a tool for detectionof toxicity
*toxicogenomics as a tool to assess immunotoxicity
*toxicogenomics and ecogenomics for studying endocrinedisruption and basic biology
*use of toxicogenomics as an early predictive tool forhepatotoxicity
*nutrigenomics: the application of genomic signatures innutrition–related research
*application of toxicogenomics in drug discovery
*potential uses of toxicogenomic biomarkers in occupationalhealth and risk assessment
*usefulness of toxicogenomics in the regulatory environment
*perspectives on toxicogenomics at the US EnvironmentalProtection Agency
Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currentlyengaged in toxicogenomics, and will also be of interest toresearchers working in toxicology, genetics, medicine,pharmacology, and food sciences, and to regulators and riskassessors of drug, food, environmental and agriculturalproductsToxicogenomics: A Powerful Tool for Toxicity Assessment [texte imprimé] / Saura C Sahu, Auteur . - [S.l.] : Wiley VCH, 2011 . - 409p : ill ; 26x 18 cm.
ISBN : 978-0-470-51823-6
Langues : Anglais (eng) Langues originales : Anglais (eng)
Index. décimale : 616 Maladies Résumé :
Toxicogenomics is the integration of genomics to toxicology. Thistechnology is a powerful tool for collecting information from alarge number of biological samples simultaneously and thus it isvery useful for large–scale screening of potential toxicants.
Toxicogenomics: A Powerful Tool For Toxicity Assessmentprovides up–to–date state–of–the–art information presented by therecognized experts, and is therefore an authoritative source ofcurrent knowledge in this field of research. The potential linkbetween toxicology, genetics and human diseases makes this bookvery useful to investigators in many and varied disciplines ofscience and toxicology. Topics covered include:
*mechanistic toxicogenomics
*analysis and interpretation of toxicogenomic data
*principles of data mining in toxicogenomics
*design issues in toxicogenomics studies
*sources of variability in toxicogenomic assays
*Escherichia coli stress response as a tool for detectionof toxicity
*toxicogenomics as a tool to assess immunotoxicity
*toxicogenomics and ecogenomics for studying endocrinedisruption and basic biology
*use of toxicogenomics as an early predictive tool forhepatotoxicity
*nutrigenomics: the application of genomic signatures innutrition–related research
*application of toxicogenomics in drug discovery
*potential uses of toxicogenomic biomarkers in occupationalhealth and risk assessment
*usefulness of toxicogenomics in the regulatory environment
*perspectives on toxicogenomics at the US EnvironmentalProtection Agency
Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currentlyengaged in toxicogenomics, and will also be of interest toresearchers working in toxicology, genetics, medicine,pharmacology, and food sciences, and to regulators and riskassessors of drug, food, environmental and agriculturalproductsRéservation
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Code-barres Cote Support Localisation Section Disponibilité 11/185947 L/616.008 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible 11/185948 L/616.008 Livre Bibliothèque Science de la nature et de la vie et sciences de la terre et de l'univers indéterminé Disponible